The Bleeding Edge – Qualia Senolytic

Poke around the ole interwebZ, and you will find no shortage of hacks and easy ways to avoid the basics.

Newsflash Brosky – you can’t escape the basics. They’re the foundations for better body comp, performance, and health.

If you have the aerobic capacity of a propanol-ed possum, get thee to the rower or bike ASAP.

Nothing will replace picking up stuff in the gym and setting it down, making sure your nutrition is not the “see-food” diet of the hoover upright to suck in whatever is in front of you, in addition to sawing logs at night.

However, once you are crushing those with violent consistency, what next?

Normally this is where (in my biased opinion) the more esoteric supplements fall.

The basic food-based ones like fish oil, protein, multi-vite, and creatine are a no-brainer. After that, it gets much more nuanced, and what you take should be related to your goals.

The pro of supplements is that it doesn’t take a lot of action on your part to take them. Just take this pill, capsule, or powder. Boom!

The downside of supplements is that many are overhyped and aren’t based on any data.

How do you evaluate new supplements?

For me, I look at the risk/reward spectrum, and hedge against any downside.

If there’s not much of a downside (e.g. appears to be safe), then I can test it out for myself to see if there is a benefit.

If the downside is horrible- as in the case with compounds like 2 4-dinitrophenol (aka DNP) that can result in death – stay the F away from them.

This is the lens through which I view new supplements, especially when there is not much human data.

Along those lines, the nerds at Neurohacker have a new supplement that is a senolytic.

Sen-a-what?

The word “senolytic” is derived from the Latin words senex (=old) and lytic (=destroying).

A senolytic is a substance designed to destroy senescent cells, making “room” in tissues for more youthful cells—promoting whole-body rejuvenation.

All the cells in your body are constantly turning over. In theory, senolytic agents help clear out the ones that are no longer doing their jobs well – like an employee that keeps bringing donuts to Planet Fitness – they should be fired, but instead, they keep showing up with said donuts thus screwing up any progress.

Neurohacker has a new senolytic product that you take only 2 days, back to back, once a month.

The idea is that it will help clear out the bad employee cells.

A few notes:

1) As I stated above, if you’re not hammering the basics into oblivion, do not start here. Side note “oblivion” is also an amazing song by Mastodon!

2) Yes, I am an affiliate for them, so I do make some coin if you opt to purchase. Use the link above and the code “DRMIKE” at check out to save an extra 15%. Note- that code will work on anything from their site.

3) I’ve tested this out myself and found that even on a very low-calorie day, my HRV and metrics the next day were quite good. I trained for 2 hours the day before also. All the caveats around n=1 testing apply here, of course.

>> Neurohacker Senolytic <<

Use the coupon code DRMIKE to save an extra 15%!

Senolytic Research

Here is a review that discusses the potential ability of exercise to be a senolytic (1).

No pill or potion will ever replace all of the benefits of exercise!

And to address another important point, the data currently on the use of senolytics is still very much in its infancy.

We have lots of mechanistic data in small rodents and cells, but not as much in humans.

One of the main ingredients in Senolytic from Neurohacker is a compound called fisetin.

Fiestin is a yellow pigment found in plants. It’s found in strawberries, apples, persimmon, grapes, onions, and cucumbers for example.

The rodent and cell data on fiestin is quite robust; but as you know- since you are a smart cookie reading this newsletter – that does not mean it will translate to humans.

Right now there are only 4 randomized controlled trials (aka RCTs- the studies that nerds get all excited about) in very different disease (2-5). The data from them is quite mixed.

There are 5 human clinical trials underway using fiestin – generally in older adults and even as a potential therapy for COVID (6-10). Hopefully in the near future we will have more data from them.

In the meantime, we know that the safety data is good and if you want to hedge your bets in the longevity space – after you are crushing the basics- adding a supplement like Senolytic is one method.

>> Neurohacker Senolytic <<

Use the coupon code DRMIKE to save an extra 15%.

Plus, using DRMIKE provides an extra 15% off any order, including subscriptions!!

This is an affiliate link, so I do make a bit of coin if you purchase.

Honestly, the amount I make is small, but I know some of you are looking for the bleeding edge to test out, so my job is to help point you in a better direction and ways to stay clear from the completely bat sheeeet crazy celery juice cleanse or cucumber enemas.

References

1) Chen XK, Yi ZN, Wong GT, Hasan KMM, Kwan JS, Ma AC, Chang RC. Is exercise a senolytic medicine? A systematic review. Aging Cell. 2021 Jan;20(1):e13294. doi: 10.1111/acel.13294. Epub 2020 Dec 30. PMID: 33378138; PMCID: PMC7811843.

2) Wang L, Cao D, Wu H, Jia H, Yang C, Zhang L. Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619871359. doi: 10.1177/1076029619871359. PMID: 31434498; PMCID: PMC6829632.

3) Hodgin KS, Donovan EK, Kekes-Szabo S, Lin JC, Feick J, Massey RL, Ness TJ, Younger JW. A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Resveratrol (Polygonum cuspidatum), Luteolin, and Fisetin (Rhus succedanea). Int J Environ Res Public Health. 2021 Mar 3;18(5):2483. doi: 10.3390/ijerph18052483. PMID: 33802381; PMCID: PMC7967624.

4) Farsad-Naeimi A , Alizadeh M , Esfahani A , Darvish Aminabad E . Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. Food Funct. 2018 Apr 25;9(4):2025-2031. doi: 10.1039/c7fo01898c. PMID: 29541713.

5) Kwak JH, Lee HJ, Jeong ST, Lee JY, Lee M, Paik JK. Effect of fermented Rhus verniciflua stokes extract on liver function parameters in healthy Korean adults: a double-blind randomized controlled trial. Trials. 2021 Nov 22;22(1):830. doi: 10.1186/s13063-021-05656-0. PMID: 34809689; PMCID: PMC8607399.

6) History of Changes for Study: NCT04771611​

7) History of Changes for Study: NCT03325322​

8) History of Changes for Study: NCT04476953​

9) History of Changes for Study: NCT03430037​

10) Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults – Full Text View – ClinicalTrials.gov

Rock on!

Dr. Mike T Nelson